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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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L1000
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
pizotifen 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
2220
15574-96-6
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
pizotyline
pizotifen
pizotifen malate
Serotonin antagonist used against MIGRAINE DISORDERS and vascular headaches.
Molecular weight: 295.44
Formula: C19H21NS
CLOGP: 4.70
LIPINSKI: 0
HAC: 1
HDO: 0
TPSA: 3.24
ALOGS: -4.62
ROTB: 0
Drug dosage:
Dose
Unit
Route
1.50
mg
O
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
78 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
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Approvals:
None
FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Vestibular migraine
75.03
44.44
10
543
225
63488244
Clonus
74.01
44.44
15
538
4621
63483848
Hyperreflexia
70.32
44.44
15
538
5919
63482550
Therapeutic response changed
60.12
44.44
10
543
1035
63487434
Muscle twitching
52.46
44.44
15
538
19653
63468816
Serotonin syndrome
51.03
44.44
16
537
28666
63459803
Endometrial cancer
48.87
44.44
10
543
3215
63485254
Dyskinesia
45.26
44.44
15
538
31987
63456482
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FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Clonus
69.65
45.89
15
614
6825
79736934
Hyperreflexia
66.61
45.89
15
614
8370
79735389
Muscle twitching
50.49
45.89
15
614
24749
79719010
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
N02CX01
NERVOUS SYSTEM
ANALGESICS
ANTIMIGRAINE PREPARATIONS
Other antimigraine preparations
CHEBI has role
CHEBI:37956
antihistamines
CHEBI has role
CHEBI:48279
serotonin antagonists
CHEBI has role
CHEBI:48876
muscarinic antagonists
MeSH PA
D000700
Analgesics
MeSH PA
D018712
Analgesics, Non-Narcotic
MeSH PA
D000928
Antidepressive Agents
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D018377
Neurotransmitter Agents
MeSH PA
D018373
Peripheral Nervous System Agents
Showing 1 to 10 of 14 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
8.8
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
D(2) dopamine receptor
GPCR
P14416
DRD2_HUMAN
Ki
8.62
CHEMBL
5-hydroxytryptamine receptor 1A
GPCR
P08908
5HT1A_HUMAN
ANTAGONIST
Ki
7.40
IUPHAR
5-hydroxytryptamine receptor 2A
GPCR
P28223
5HT2A_HUMAN
Ki
8.12
CHEMBL
5-hydroxytryptamine receptor 2B
GPCR
P41595
5HT2B_HUMAN
Ki
8.70
CHEMBL
5-hydroxytryptamine receptor 2C
GPCR
P28335
5HT2C_HUMAN
Ki
8.85
CHEMBL
5-hydroxytryptamine receptor 7
GPCR
P34969
5HT7R_HUMAN
Ki
7.60
CHEMBL
Muscarinic acetylcholine receptor M1
GPCR
P11229
ACM1_HUMAN
Ki
8.70
CHEMBL
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External reference:
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ID
Source
003497
NDDF
0BY8440V3N
UNII
2693
INN_ID
27400
PUBCHEM_CID
349963006
SNOMEDCT_US
395834002
SNOMEDCT_US
8373
RXNORM
93
IUPHAR_LIGAND_ID
C0032036
UMLSCUI
CHEBI:50212
CHEBI
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Pharmaceutical products:
None
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pizotifen